Agonist-induced localized Ca2+ spikes directly triggering exocytotic secretion in exocrine pancreas.
نویسندگان
چکیده
منابع مشابه
Characterization of Ca2+-activated protein phosphatase activity in exocrine pancreas.
Ca2+-activated protein phosphatase activity was demonstrated in mouse pancreatic acinar cytosol with alpha-casein and skeletal-muscle phosphorylase kinase as substrates. This phosphatase activity preferentially dephosphorylated the alpha subunit of phosphorylase kinase. After DEAE-cellulose chromatography, the Ca2+-activated phosphatase activity became dependent on exogenous calmodulin for maxi...
متن کاملUnstimulated Secretion of Protein from Rat Exocrine Pancreas Cells
Our earlier work demonstrated that the rate of protein synthesis in the exocrine cells of the rat pancreas is constant in different physiological states, including prolonged fasting. In this study we have followed the fate of the protein in the pancreatic cells of the fasting animal in vivo as well as in vitro. The data were obtained by quantitative radioautography and by biochemical determinat...
متن کاملGap junctional coupling modulates secretion of exocrine pancreas.
Dispersed pancreatic acini were studied to assess the function of junctional coupling between adult secretory cells. Nonstimulated control cells were extensively coupled to their neighbors throughout each acinus. Addition of heptanol caused their uncoupling and increased their basal amylase release. Neurotensin, secretin, and vasoactive intestinal peptide (VIP) stimulated amylase secretion with...
متن کاملEffects of g-aminobutyric acid on secretagogue-induced exocrine secretion of isolated, perfused rat pancreas
Park, Hyung Seo, and Hyoung Jin Park. Effects of g-aminobutyric acid on secretagogue-induced exocrine secretion of isolated, perfused rat pancreas. Am J Physiol Gastrointest Liver Physiol 279: G677–G682, 2000.—Because GABA and its related enzymes have been determined in b-cells of pancreas islets, effects of GABA on pancreatic exocrine secretion were investigated in the isolated, perfused rat p...
متن کاملEffects of gamma-aminobutyric acid on secretagogue-induced exocrine secretion of isolated, perfused rat pancreas.
Because GABA and its related enzymes have been determined in beta-cells of pancreas islets, effects of GABA on pancreatic exocrine secretion were investigated in the isolated, perfused rat pancreas. GABA, given intra-arterially at concentrations of 3, 10, 30, and 100 microM, did not exert any influence on spontaneous or secretin (12 pM)-induced pancreatic exocrine secretion. However, GABA furth...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: The EMBO Journal
سال: 1993
ISSN: 0261-4189
DOI: 10.1002/j.1460-2075.1993.tb05970.x